Photolabile Dendrimers…

…which are in many ways conceptually similar to Shabat’s self-immmolative dendrimers were published by Kevwitch and McGrath in the recent issue of New J. Chem. (DOI: 10.1039/b617289j). These dendrimers contain o-nitrophenyl linkers in the core, which allow the controlled degradation of the material:

light-sensitive-dendrimer.gif

The photolabile core can be prepared from piperonal in a relatively straightforward way. As was the case for the self-immolative dendrimers, a trigger event – in this case irradiation – leads to the fragmentation of the dendrimer. In this case, the dendrons detach from the core – no complete unraveling of the architecture occurs.

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